Customer Experience and The Science of CBD Oil
We've recently received this wonderful customer note on their use of our CBD formulas: "Thank you for being available - your CBD oil removed be from 60 mg morphine, 325 mg Effexor thyroid med, Lyrica & Cymbalta ... even my hormones balanced. Please share this!
What is CBD?
CBD is shorthand for cannabidiol, one of more than one hundred cannabinoids present in cannabis, and 'industrial' hemp, grown for hempseed, hempseed oil, and fiber. The amounts of certain cannabinoids, along with other constituents such as terpenes, ketones, and aldehydes, to name a few (found in hemp essential oil) account for the wide variety of effects of various cannabis strains.
CBD Formulas for ingestion are available at The Ananda Apothecary. See our selection of several blends here. *
Hemp, which is legal in all 50 states, contains a relatively high concentration of CBD, and only trace amounts of other cannabinoids such as THC, CBN, etc. This allows for the CO2-extraction of CBD, and the formulation of CBD-containing blends used via oral ingestion.
CBD has none of the effects commonly associated with 'pot'. It doesn't get one 'high', though it has been researched for many potential health benefits.
CBD has been studied for a vast amount of potential health benefits, including neuralgic pain, anti-cancer properties, depression, anxiety, antibiotic resistance, and much, much more. Much of the research thus performed can be viewed at ProjectCBD.org/conditions.
CBD and Pain
In a recent Scientific American article, Lester Grinspoon, professor emeritus of psychiatry at Harvard Medical School in Boston, Mass., who has studied the effects of marijuana on patients since 1967, says that Curran's study is important. "Cannabis with high cannabidiol (CBD) levels will make a more appealing option for anti-pain, anti-anxiety and anti-spasm treatments, because they can be delivered without causing disconcerting euphoria," he says.
Published in the European Journal of Pharmacology, 2007 Epub 2006 Nov 10, is this research titled: "The non-psychoactive cannabis constituent cannabidiol (CBD) is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain.
Abstract summary: Cannabidiol CBD), the major psycho-inactive component of cannabis, has substantial anti-inflammatory and immunomodulatory effects. This study investigated its therapeutic potential on neuropathic and inflammatory pain in rats. In both models, daily oral treatment with cannabidiol (2.5-20 mg/kg to neuropathic and 20 mg/kg to adjuvant-injected rats) from day 7 to day 14 after the injury, or intraplantar injection, reduced hyperalgesia to thermal and mechanical stimuli.
The compound's efficacy on neuropathic pain was not accompanied by any reduction in nuclear factor-kappaB (NF-kappaB) activation and tumor necrosis factor alpha (TNFalpha) content. The results indicate a potential for therapeutic use of cannabidiol in chronic painful states.
CBD and Cancer
The body of research noting CBD as a potential anti-cancer agent is growing as well. Published in the British Journal of Pharmacol, Oct 2014 is a study titled: "Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer."
Abstract: The psychoactive cannabinoid Δ9-tetrahydrocannabinol (THC) and the non-psychoactive cannabinoid cannabidiol (CBD) can both reduce cancer progression, each through distinct anti-tumour pathways. Our goal was to discover a compound that could efficiently target both cannabinoid anti-tumour pathways.
To measure breast cancer cell proliferation/viability and invasion, MTT and Boyden chamber assays were used. Modulation of reactive oxygen species (ROS) and apoptosis was measured using dichlorodihydrofluorescein and annexin/propidium iodide, respectively, in combination with cell flow cytometry. Changes in protein levels were evaluated using Western analysis. Orthotopic and i.v. mouse models of breast cancer metastasis were used to test the activity of cannabinoids in vivo.
Key Results: CBD reduced breast cancer metastasis in advanced stages of the disease as the direct result of down-regulating the transcriptional regulator Id1.
This is just a peek into the potential of CBD. We've made it available in synergistic blends, which many customers have enjoyed. Again, for further reading on the research of CBD, see projectcbd.org/conditions.
* These statements have not been evaluated by the FDA. These products are not intended to prevent, treat, or cure any disease.